Comodo, anything else won't suffice as other programs is not as sophisticated as comodo in terms of HIPS and Sandbox. There is only one way to bypass Comodo and that is to obtain a stolen SSL certificated which will be fixed in the next release of the program .
I use AVG antivirus in my PC and also in my mobile as its having android O.S. Its the best anti virus as it completely protect our PC form viruses and the best thing is that when any of the external drives like pen drive or hard disk etc are attached to PC, AVG will first scan the entire drive and then allow access to it, if any virus is detected then the AVG would deleted that thread.