The Mass Effect 3 box art found alongside this article was posted then removed promptly on the EA Store yesterday.
In case you didn’t notice it, the narrow purple band above the game’s logo states that the game is “Better With Kinect Sensor.”
The game was originally schedule for release this year, but was delayed to 2012 with the addition of "some new ways to play" as the main reason given.
The note on the box art indicates that the game is playable without Kinect. It is reasonable to speculate if the game will use hand gestures or voice commands to give orders to squad members.
Haven't played it, only read reviews and what mates have told me, I heard #2 is FAR better than #1 though, like a tremendous difference, also the GUI is apparently far more advanced too because Mass Effect 2 came out same time a new engine came out.